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Otolaryngology
infectious conditions
mucormycosis
A 62-year-old male, with a history of poorly controlled diabetes mellitus and recent treatment for acute myeloid leukemia, presents to his primary care physician's office reporting a 5-day history of worsening unilateral right-sided facial pain, headache, and blurry vision. He initially attributed these symptoms to a viral infection, but they have not responded to a course of oral azithromycin prescribed by an urgent care clinic. On examination, he exhibits right periorbital edema, significant proptosis, ophthalmoplegia, and an anesthetic area along the distribution of the infraorbital nerve on the right side. There is a dark, necrotic eschar visible on the right inferior turbinate. His current laboratory findings are provided. A CT scan of the paranasal sinuses reveals extensive opacification, bony destruction of the right ethmoid and maxillary sinuses, and extension into the orbit. Considering his underlying medical conditions and the rapid progression of symptoms, what is the most likely diagnosis and the immediate critical intervention required?
| Lab Parameter | Value | Reference Range |
|---|---|---|
| Leukocyte count | 16.5 × 10^9/L | 3.5–10.5 × 10^9/L |
| Hemoglobin | 105 g/L | 130-170 g/L |
| Platelets | 145 × 10^9/L | 130–380 × 10^9/L |
| C-Reactive Protein | 72.3 mg/L | ≤ 10 mg/L |
| Erythrocyte Sedimentation Rate | 88 mm/hr | 0-20 mm/hr |
| Creatinine | 85.2 µmol/L | 50–100 µmol/L |
| Blood urea nitrogen | 6.8 mmol/L | 2.5–8.0 mmol/L |
| Fasting Blood Glucose | 16.8 mmol/L | 3.9-6.1 mmol/L |
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